Frenkie de Jong and Matthijs de Ligt look to have played their final games for Ajax as the Dutch giants clinched the league title with a 4-1 win at De Graafschap on Wednesday.
De Jong is a certain departure having already agreed a £65million deal to move to Barcelona but it is expected that a number of his team-mates will find new clubs this summer.
Hakim Ziyech, De Ligt, Donny van de Beek and Nicolas Tagliafico could all win lucrative moves away in a summer which could see this talented young side decimated.
Ajax have been a revelation this season and have caught the eye of Europe's elite clubs on their surging run to the semi-finals of the Champions League where they were dramatically between in the final seconds by Tottenham.
Domestically they ended three points clear of PSV Eindhoven, who won 3-1 at home to Heracles Almelo on the last day of the campaign.
It represents Ajax's first title since 2014 and a record-extending 34th overall as they completed the double having already won the KNVB Cup earlier this month.
Ajax had been neck-and-neck with PSV over the last few weeks, but made all but sure of the title on Sunday when they beat Utrecht while defending champions PSV lost.
That allowed Ajax to take a three-point advantage, plus a massive plus 14 goal difference, into Wednesday's match.
Dusan Tadic scored twice against De Graafschap as Ajax said farewell to potentially a number of key players.
Ajax ended with 86 points and 119 goals scored in 34 games. PSV collected 83 points to join them in next season's Champions League.
Feyenoord came third after winning 4-1 at Fortuna Sittard, the last game in charge for their coach Giovanni van Bronckhorst.