captain Antonio Valencia is set to leave at the end of the season when his contract expires.
The Red Devils have until March to extend Valencia's contract by a further 12 months but they do not have plans to do so.
Inter Milan are now the front runners to sign the Ecuador international in the summer.
According to the Mirror
, Valencia's advisers have already started negotiating with the Serie A club.
Inter would like to sign the 33-year-old now but United are reluctant to weaken Ole Gunnar Solskjaer's side.
The Red Devils skipper fell out with sacked Manchester United boss Jose Mourinho earlier in the season.
This has limited Valencia to just five Premier League appearances this campaign.
Interim boss Solskjaer has now restored him back to the team as the full-back played his first league game against Newcastle since September.