Liam Williams will start at full back and Gareth Anscombe returns to the No 10 shirt for Wales against South Africa this weekend.
Warren Gatland has reverted to the team that beat Australia 9-6 a fortnight ago, with one change – Williams coming in for the concussed Leigh Halfpenny.
It means there is no place for Dan Biggar, who makes the replacements bench, as Gatland continues to show faith in the converted-Kiwi playmaker Anscombe.
Wales team to play South Africa
L Williams (Saracens); G North (Ospreys), J Davies (Scarlets), H Parkes (Scarlets), J Adams (Worcester); G Anscombe (Cardiff Blues), G Davies (Scarlets); N Smith (Ospreys), K Owens (Scarlets), T Francis (Exeter), A Beard (Ospreys), A W Jones (Ospreys, capt), D Lydiate (Ospreys), J Tipuric (Ospreys), R Moriarty (Dragons).
Replacements: E Dee (Dragons), R Evans (Scarlets), D Lewis (Cardiff Blues), C Hill (Dragons), E Jenkins (Cardiff Blues), T Williams (Cardiff Blues), D Biggar (Northampton), O Watkin (Ospreys).
'We have rewarded the team that faced Australia with another start this weekend,' said head coach Gatland.
'Leigh (Halfpenny) misses out with concussion but it's a great opportunity for Liam (Williams) at full back.
'We are really pleased with how the bench has gone in the first three games so we will be looking for that impact again on Saturday.
'There were a lot of tough selection calls, but that is what we want. The team that played last week was hugely impressive and there are some disappointed boys who miss out.
'We want to end the campaign with a big performance against a very good South African side.'
Adam Beard retains his place in the second row, as Cory Hill stays on the bench. Alun Wyn Jones wins his 120th Welsh cap – he continues to captain the side from lock.
Wales have won the last eight matches in a row and are looking to complete a first-ever autumn clean sweep.